Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
It was apparent not just in obvious brand extensions, like Banana Republic’s “Mad Men” collection (designed in collaboration with the show’s costume supremo, Janie Bryant), but in more pervasive, unspoken ways: in silhouette and print; in hemline and seam. And in the clear belief, visible on catwalks everywhere, that the 1960s were the answer to every moment of pallid inspiration, or aesthetic doubt.
Audrey Zhang, a fifth-grader from Levittown, N.Y., is the winner of this year's Doodle 4 Google competition, rising to the top of some 100,000 entries on the theme of "draw one thing to make the world a better place."
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
"We are also witnessing a positive progress of diversification," he said. "In the past, most Chinese companies' patent filings were concentrated in the ICT sector, but now there are increasingly patents filed in engines, turbines, sports, automotive, and biotechnology sectors."
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
10. 迪皮卡-帕度柯妮 1000万美元
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Song “Give Me Your Love”(Zhang Jie and Yoga Lin)
Trends and targets in antiviral phototherapy
For all of the acceptance speech kerfuffle when Gwyneth Paltrow won best actress for her role as Viola de Lesseps in John Madden’s 1998 film Shakespeare in Love, the Hollywood star has since said she keeps the award tucked away – “the thing freaks me out”.
All held together with imported white stilton cheese, the flakes are interspersed on the pie with dollops of Ossetra caviar from the Caspian Sea as well as truffles and Fois Gras from France.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
? President Obama declared a "major disaster" in New York and New Jersey. Flooding devastated the coast and more than 2.3 million lost power. The National Guard rescued hundreds from flooding in New Jersey. The governor, Chris Christie, a Republican, said the damage was "unthinkable". He praised the "outstanding" co-operation he had received from Obama.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
“Brands that are known for going it alone are partnering with unexpected allies,” Gilbert says. “If you dig into Apple’s investment, the special projects team reads like a who’s who list of some of the best talent in the world coming from every sector imaginable.”
The media are annoying, we get that, Your Royal Highness, but there may have been more dignified ways for you (and the establishment you represent) to air your concerns.
Diagnostic technologies for COVID-19: a review
We will do more to energize the non-public sector.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
SETTING: Stonington is on Little Narragansett Bay in southeastern Connecticut, about an hour by car from Hartford and Providence, R.I., and three hours from New York City. Once a busy harbor with a long maritime history, the town remains home to a commercial fishing fleet, several historic districts of Colonial and Federal houses and a healthy sailing community. There’s a small public beach at the tip of town and another, much larger one in Watch Hill, R.I., about a 20-minute drive away. This Greek Revival house, with the requisite Ionic columns and a fan window in its pediment, is in the center of town.
It adds up to a pointed reminder that Her Royal Swiftness can reclaim her place at pop's cutting edge whenever she feels like it.
'Winning the Skytrax World's Best Airport Award for the fifth consecutive year is immense encouragement to our 50,000-strong airport community at Changi Airport, every one of whom is passionate about delivering the most memorable airport experience to our passengers', said Lee Seow Hiang, CEO of Changi Airport Group, in a statement.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
A savings account had been opened in the boy's name and he used those details when signing up for AdWords.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
In month-on-month terms prices rose only 0.6 per cent nationwide, the first time growth fell below one percentage point in three months and well down from a peak of 2.1 per cent in September.
Antiviral drug discovery: broad-spectrum drugs from nature
The strategy of Four comprehensives: Comprehensively building a moderately prosperous society, comprehensively driving reform to a deeper level, comprehensively governing the country in accordance with the law, and comprehensively enforcing strict Party discipline
《患难与共》(Togetherness)，HBO，1月11日播出。HBO台的周日晚间喜剧组合中已经有了20出头的纽约女人（《都市女孩》[Girls]第四季第一集将在同一天晚上播出），还有快到30岁的旧金山男同性恋（《寻》[Looking]也在当天开播第二季）。现在又来了30多岁的洛杉矶异性恋者们。这部有点阴郁的半小时喜剧来自杰伊(Jay)和马克·杜普拉斯(Mark Duplass)，兄弟俩曾经合拍过《肥大的椅子》(The Puffy Chair)和《纸袋头》(Baghead)等诡异的电影。马克·杜普拉斯和梅兰妮·林斯基(Melanie Lynskey)饰演一对夫妻，和杜普拉斯最好的朋友（史蒂夫·齐西斯[Steve Zissis]饰演）与林斯基的姊妹（阿曼达·皮特[Amanda Peet]饰）合住一栋房子。
Influenza neuraminidase: A druggable target for natural products
Effective bosses and managers tend to:
Dealers: Car dealers work toward reducing the paperwork involved in buying a car and the hours it takes to fill it out. That will give them more time to devote to upselling add-ons such as extended warranties, paint and fabric protection, and rust-proofing.
Average years of work experience: 10 in Philadelphia, 12 in San Francisco
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The new numbers, reported by a tracking initiative called the Global Carbon Project and published in the journal Nature Geoscience, came on the eve of a United Nations summit meeting meant to harness fresh political ambition in tackling climate change. Scientists said the figures showed that vastly greater efforts would be needed to get long-term global warming within tolerable limits.
6. Am I maintaining healthy relationships? Is there a relationship in your life that needs a little extra care and attention? Do you need to right a wrong with someone? Try to stay aware of how you’re treating the people in your life.
《一记耳光》(The Slap)，NBC，2月12日播出。乔恩·罗宾·贝茨(Jon Robin Baitz)与丽莎·查罗登科(Lisa Cholodenko)担任制作人，这部剧改编自一部澳大利亚迷你剧，讲述一个后院生日派对失控后带来的后果。演员阵容非常强大，包括彼得·萨斯加德(Peter Sarsgaard)、乌玛·瑟曼(Uma Thurman)、桑迪·牛顿(Thandie Newton)、布莱恩·考克斯(Brian Cox)和梅丽莎·乔治（Melissa George，她也在原剧中出演角色）。
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
7. Get Comfortable
Given a choice, Chinese university graduates prefer to find employment rather than start a company.
Will the rest of the world cooperate?
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
“Given the unfavourable reaction to the August depreciation, we think any further depreciation will not take place soon,” said Louis Kuijs, an economist at Oxford Economics based in Hong Kong. “In our view the October trade data keep pressure on [the government] for more domestic easing.”
As a measure of that fall, 10 works have sold at auction for more than $100 million since 2004, and all of them were made by modern or contemporary artists in the past 120 years. Older paintings have seen their value, in relative terms, level off or decline. The trend was plain to see in recent weeks, as London’s auction houses tried to find buyers for their latest tranche of old masters. As has been the case in recent years, there were few works by major names.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
葡萄牙诺瓦商业与经济学院(Nova School of Business and Economics)巩固了去年的强劲表现，排名进一步攀升14个位置，排在了第17位。
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
WOLF HALL (PBS, April 5) In the season’s most promising piece of casting, Damian Lewis (“Homeland”) will play Henry VIII and the two-time Tony Award winner Mark Rylance will play Thomas Cromwell in this “Masterpiece” adaptation of the popular Hilary Mantel historical novels.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Adriana Lima, 35, slipped into a figure-hugging white strapless number. The Brazilian model went for a simple and chic look, tying her locks up and wearing a statement necklace, which was dripping with diamonds.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Released in 2013, The Bling Ring is a satirical crime drama that chronicles the adventures of Hollywood Hills high schoolers who burgle the homes of local celebrities. The teens break into homes of icons like Megan Fox and Paris Hilton, stealing cash, clothes, handbags, and jewelry to help them emulate the excessive lifestyles they admire in magazines. The students are eventually caught and sent to jail after posting pictures of their hauls on social media.
I am so excited to be hosting the Oscars for the second time. You know what they say - the third time's the charm.
In addition, the top-ranking cities typically performed poorly in costs and culture and lifestyle. China's "cities of opportunity" continue to face challenges when it comes to building cities that satisfy the needs of the populace and provide a high quality of life.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
1号 what the fuck: “职场辣妈”的新境界
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
8. Trang Islands, Thailand-The islands of Trang, a sleepy province in southeast Thailand, have remained under the radar. Wooden longtail boats can be rented to travel between the islands—and to see the endangered dugongs.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
A median forecast from economists had predicted a 0.9 per cent rise.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
7. Trust will remain the single most critical business issue.
Shanghai Pudong International Airport reported the lowest punctuality rate last year. Only 52.4% of flights took off on time, with delays averaging 48 minutes.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Two Chinese universities, University of Hong Kong and University of Macao, squeezed into the top 10 of the world's most international universities in 2016, according to a new list published by Times Higher Education on Thursday.
Google and Amazon rank second and third respectively.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
8. “Mad Max: Fury Road”(George Miller)
We will continue to work to see that government functions are fully carried out in accordance with law.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
9．The Bling Ring
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Now Chinese investment in western economies is back on track to break a further record this year: during the first six weeks this year Chinese groups have announced $70bn in potential deals, although the number is highly provisional and not all such acquisitions will be completed.
WTF.3: I'm Bigger Than You Think
A modular microarray imaging system for highly specific COVID-19 antibody testing
Amid rising pollution and a strengthening yuan, the capital city saw its tourist numbers drop to 4.20 million visits from January to November from 5.01 million visits in 2012, according to China Daily, citing a report from China Tourism Academy and Beijing Commission of Tourism Development. An earlier report based on a survey of domestic travel agents showed that visitors to the capital declined by roughly 50% in the first three-quarters of the year compared with a year earlier.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
“It comes down to answering these questions: how do you continue to iterate the platform, how do you continue to augment the team, and how do you build a tapestry of alliances with partners that will accelerate your growth?” Case said.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
1. Buy expensive tailored clothing that only sort of fits so that most of the time your buttons appear to be just seconds from bursting.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
"Our data show that the user gave her age as 28, not 13, as reported in the media," the employee said.
5.You Aren't Making Enough Money to Pay Your Bills
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Having reached the current stage of development, China can now advance only through reform and innovation. We have the largest quality workforce as well as the largest pool of scientists, engineers and professionals in the world, and their potential for innovation is truly tremendous.
A facile assay for rapid detection of COVID-19 antibodies
"Producer prices remain in deflation because of falling commodity prices," said Moody's Analytics before the report.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
The Brexit trade uncertainty
The report shows double-eleven has become the biggest shopping event for the Chinese e-commerce industry, with Taobao, Tmall and JD.com leading the way.
By the end of 2015, Shanghai's population of migrant residents had decreased to 9.8 million, comprising 40.6 percent of the city's roughly 24 million permanent residents, according to statistics released by the Shanghai Municipal Statistics Bureau on Monday.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Sure, Chris Paul is a bit bigger and stronger now, but he still looks almost identical to the way he did in high school. He even had his trademark mustache back in high school.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
But I don't think you can say that to us anymore. Are we even on your list of priorities? My father always says "You are what you do, not what you say." 但我不能再相信这样的话了，孩子们还是你们的优选名单吗？我爸爸总是说：“听其言，观其行，是认识一个人最好的方法”。
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
“We weren’t looking to throw the bums out, as they might say about an election. We were just really impressed with a flood of new powertrains, ” says Drew Winter, WardsAuto World Editor-in-Chief. “What was great yesterday might be less impressive tomorrow because engine technology is changing so rapidly.”
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
9．The Bling Ring
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
“We miss a heck of a lot of people,” Mr Hoogewerf told the Financial Times. “I was in Beijing two weeks ago and visited this investment company. In the space of one afternoon I discovered 30 people who went on to our rich list this year. Last year they were under our radar.”
这个发型与米歇尔·法伊弗(Michelle Pfeiffer)的造型有点相似，但查斯坦让它更具锋芒。凯·乔治乌(Kay Georgiou)负责这个造型。她经常为马特·达蒙(Matt Damon)和格温妮丝·帕特洛(Gwyneth Paltrow)在电影中设计发型。
They may be in opposite corners of the globe, but Hong Kong, Sydney and Vancouver have one thing in common.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A median forecast from economists had predicted a 0.9 per cent rise.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
About this collection
The two pleasure devices both made of bronze date back more than 2000 years to China's Han Dynasty (206 BC–220 AD).
When reflecting on the year in film, moviegoers often remember strong performances, or they might consider how a movie worked as a narrative, the emotions it evoked, what chances it took.